Procoagulant Activity in Trauma Patients

Procoagulant activity in trauma patients.

Elevated levels of circulating procoagulants like tissue factor may increase the risk of systemic coagulation activation, thrombin generation, and consumptive coagulopathy. I measured procoagulant activity in plasma by using a clot-based assay that incorporated normal plasma to replace missing factors, corn trypsin inhibitor to block contact activation, factor VIIa to improve sensitivity to tis...

Procoagulant activity in gastroenterology.

Circulating microparticles and procoagulant activity in elderly patients.

BACKGROUND Microparticles (MP) are shed membrane vesicles released from activation or apoptosis of several cell types and carry a procoagulant activity. Age is associated with a procoagulant state, but the role of MP in this setting is unknown, as the relationship of MP to aging in humans. We tested the hypotheses that elderly persons compared with young persons may have different patterns of e...

Cyclosporine enhances platelet procoagulant activity.

BACKGROUND Clinical use of cyclosporine (CsA) was suggested to be associated with an increased risk of thromboembolic complications. The molecular mechanisms underlying these effects remain unresolved. METHODS We tested the hypothesis that CsA may produce platelet procoagulant activity due to its interaction with the platelet plasma membrane. To verify this hypothesis the possible relationshi...

Procoagulant Activity of Adherent Platelets

........................................................................................................................ 9 INTRODUCTION ............................................................................................................... 11 REVIEW OF THE LITERATURE ...................................................................................... 13 1. Platelets .....................